Analogously, here we introduce TextGrad, a versatile framework that performs optimization by backpropagating LLM-generated feedback to improve AI systems. By leveraging natural language feedback to critique and suggest improvements to any part of a system—from prompts to outputs such as molecules or treatment plans—TextGrad enables the automatic optimization of generative AI systems across diverse tasks. We demonstrate TextGrad’s generality and effectiveness through studies in solving PhD-level science problems, optimizing plans for radiotherapy treatments, designing molecules with specific properties, coding, and optimizing agentic systems. TextGrad empowers scientists and engineers to easily develop impactful generative AI systems.
材料科学Material Sciences
Large recoverable elastic energy in chiral metamaterials via twist buckling
Here, to address this challenge, we construct high-enthalpy elastic metamaterials from freely rotatable chiral metacells. Compared with existing non-chiral lattices, the non-optimized chiral metamaterials simultaneously maintain high stiffness, sustain larger recoverable strain, offer a wider buckling plateau, improve the buckling strength by 5–10 times, enhance enthalpy by 2–160 times and increase energy per mass by 2–32 times. These improvements arise from torsional buckling deformation that is triggered by chirality and is absent in conventional metamaterials. This deformation mode stores considerable additional energy while having a minimal impact on peak stresses that define material failure. Our findings identify a mechanism and provide insight into the design of metamaterials and structures with high mechanical energy storage capacity, a fundamental and general problem of broad engineering interest.
Here, as a proof of concept, we demonstrate the simultaneous and independent generation of a real-space broadband vortex or a holographic image alongside resonant momentum-space vortex beams with a narrow bandwidth, which cannot be achieved with conventional methods. Such engineered disorder contributes to vast intrinsic freedoms without adding extra dimensions or compromising the optical flatness. Our findings of real–momentum duality not only lay the foundation for disorder engineering in topological photonics but also open new avenues for optical wavefront shaping, encryption and communications.
医学Medicine
Human-correlated genetic models identify precision therapy for liver cancer
Here we generated a suite of genetically driven immunocompetent in vivo and matched in vitro HCC models. Our models represent multiple features of human HCC, including clonal origin, histopathological appearance and metastasis. We integrated transcriptomic data from the mouse models with human HCC data and identified four common human–mouse subtype clusters. The subtype clusters had distinct transcriptomic characteristics that aligned with the human histopathology. In a proof-of-principle analysis, we verified response to standard-of-care treatment and used a linked in vitro–in vivo pipeline to identify a promising therapeutic candidate, cladribine, that has not previously been linked to HCC treatment. Cladribine acts in a highly effective subtype-specific manner in combination with standard-of-care therapy.
地球科学Earth Science
High temporal variability not trend dominates Mediterranean precipitation
地中海降水以高时间变异性不占主导地位
▲ 作者：Sergio M. Vicente-Serrano, Yves Tramblay et al.
Here we show that Mediterranean precipitation has largely remained stationary from 1871 to 2020, albeit with significant multi-decadal and interannual variability. This conclusion is based on the most comprehensive dataset available for the region, encompassing over 23,000 stations across 27 countries. While trends can be identified for some periods and subregions, our findings attribute these trends primarily to atmospheric dynamics, which would be mostly linked to internal variability. Furthermore, our assessment reconciles the observed precipitation trends with Coupled Model Intercomparison Project Phase 6 model simulations, neither of which indicate a prevailing past precipitation trend in the region. The implications of our results extend to environmental, agricultural and water resources planning in one of the world’s prominent climate change hotspots.
教育学Education
Children’s arithmetic skills do not transfer between applied and academic mathematics
儿童的算术技能不会在应用数学和学术数学之间转化
▲ 作者：Abhijit V. Banerjee, Swati Bhattacharjee et al.
Here we surveyed children in Kolkata and Delhi, India, who work in markets (n = 1,436), to investigate whether maths skills acquired in real-world settings transfer to the classroom and vice versa. Nearly all these children used complex arithmetic calculations effectively at work. They were also proficient in solving hypothetical market maths problems and verbal maths problems that were anchored to concrete contexts. However, they were unable to solve arithmetic problems of equal or lesser complexity when presented in the abstract format typically used in school. The children’s performance in market maths problems was not explained by memorization, access to help, reduced stress with more familiar formats or high incentives for correct performance. By contrast, children with no market-selling experience (n = 471), enrolled in nearby schools, showed the opposite pattern. These children performed more accurately on simple abstract problems, but only 1% could correctly answer an applied market maths problem that more than one third of working children solved (β = 0.35, s.e.m. = 0.03; 95% confidence interval = 0.30–0.40, P < 0.001). School children used highly inefficient written calculations, could not combine different operations and arrived at answers too slowly to be useful in real-life or in higher maths. These findings highlight the importance of educational curricula that bridge the gap between intuitive and formal maths.
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